Our Science
Biology maps targets CODON provides ligands Chemical Biology powers drug discovery
Our approach
Chemical biology is at our core. It's the glue connecting chemistry and biology to reveal how to drug the hardest targets.
Origins
Biology maps the targets. We follow that signal even when conventional approaches fall short.
The foothold
Every breakthrough starts with a foothold. Covalent chemistry lets us engage and unlock undruggable targets.
Our CODON library includes >12,000 covalent ligands, designed with low promiscuity and tuned to access transient cryptic pockets.
Fit to target
There is no playbook for undruggable targets.
Our approach is flexible by necessity.
We combine protein structure and computation to evolve covalent hits into high-quality leads, aligning modality with biology.
Pharmacology is tailored to each target, with integrated PK/PD modeling guiding optimization from leads to drug candidates.