We are pursuing drugs
for some of the most
elusive targets

For many diseases, biology reveals the most compelling drug targets, yet drug discovery struggles to reach them. We're unlocking these undruggable targets through chemical biology and pharmacology enabled by covalent ligand discovery across all nucleophilic amino acids.

Targets of Current Drugs

proteins with well-defined
binding pockets

kinases and other enzymes
GPCRs | hormone receptors

20%
80%
Covalent Ligand Discovery

Captures shallow, challenging and transient pockets.

Undruggable Targets

proteins without well-defined
binding pockets

intrinsically disordered proteins
scaffolding proteins | transcription factors

proteins with challenging
binding pockets

paralogs | protein-protein interfaces

Illustration of current drug targets versus undruggable targets.

Targets of Current Drugs

proteins with well-defined
binding pockets

kinases and other enzymes
GPCRs | hormone receptors

Undruggable Targets

proteins without well-defined
binding pockets

intrinsically disordered proteins
scaffolding proteins | transcription factors

proteins with challenging
binding pockets

paralogs | protein-protein interfaces

20%
80%
Covalent Ligand Discovery

Captures shallow, challenging and transient pockets.